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Putting Patients First

We aim to make our process as easy as possible, and we’re happy to provide the following services to assist you:

Convenient text message reminders (opt-in required) to keep you up to date on the status of your prescription and refill schedule.

Shipment tracking so you know when to expect your DIACOMIT delivery.

Pharmacists on call 24/7 and translation services in 100+ languages to answer your questions or concerns about your child’s DIACOMIT prescription.

A dedicated Rare Care team that understands Dravet syndrome and DIACOMIT treatment so it can advocate for your child.

A team ready to resolve issues with insurance coverage and prior authorization, so you don’t have to.

Risks	Recommendations
Phenylketonuria* *DIACOMIT for oral suspension contains phenylalanine, but DIACOMIT capsules do not.	Reduce clobazam by 25%. Further reduce by an additional 25% if somnolence persists and adjust dosage of other concomitant anticonvulsant drugs with sedating properties. Assess for central nervous system depressants, including alcohol, which may increase risk.
Decreased DIACOMIT concentrations due to induction-based interactions	Avoid concomitant use of strong inducers or adjust doses. These may include CYP1A2, CYP3A4, or CYP2C19 inducers, such as rifampin, phenytoin, phenobarbital, and carbamazepine.
Effects on other drugs	Reduce doses of subtrates of CYP2C8, CYP2C19, P-gp, and BCPR. These may include diazepam or clopidogrel (CYP2C19), carbamazepine (P-gp), and methotrexate, prazosin, or glyburide (BCRP).
Neutropenia and thrombocytopenia	Monitor patients for neutropenia or thrombocytopenia. Hematologic testing should be obtained prior to starting treatment and then every 6 months

Phenylketonuria*
Reduce clobazam by 25% from DIACOMIT for oral suspension and all other sources *DIACOMIT for oral suspension contains phenylalanibe, but DIACOMIT capsules do not.
Decreased DIACOMIT concentrations due to induction-based interactions
Avoid concomitant use of strong inducers or adjust doses. These may include CYP1A2, CYP3A4, or CYP2C19 inducers, such as rifampin, phenytoin, phenobarbital, and carbamazepine.
Effects on other drugs
Reduce doses of subtrates of CYP2C8, CYP2C19, P-gp, and BCPR. These may include diazepam or clopidogrel (CYP2C19), carbamazepine (P-gp), and methotrexate, prazosin, or glyburide (BCRP).
Neutropenia and thrombocytopenia
Monitor patients for neutropenia or thrombocytopenia. Hematologic testing should be obtained prior to starting treatment and then every 6 months

	6 MONTHS TO 1 YEAR^a,b	1 YEAR AND OLDER
BODY WEIGHT	15 lb +	15 lb – 22 lb^b	22 lb +
STEP 1 Convert weight to kilograms	15 lb = 7 kg	18 lb = 8.2 kg	30 lb = 13.6 kg
STEP 2 Multiply by 50 mg	7 kg x 50 mg = 350 mg/kg	8.2 kg x 50 mg = 410 mg/kg	13.6 kg x 50 mg = 680 mg/kg
STEP 3 Round to nearest dose (250 mg increments)	Round up to 500 mg	Round up to 500 mg	Round up to 750 mg
STEP 4 Divide total into 2 or 3 daily doses	Divide into 2 doses/day: 250 mg + 250 mg	Divide into 2 doses/day: 250 mg + 250 mg	Divide into 2 doses/day: 250 mg + 500 mg – OR – Divide into 3 doses/day: 250 mg + 250 mg + 250 mg

6 MONTHS TO 1 YEAR^a,b
BODY WEIGHT	15 lb +
STEP 1 Convert weight to kilograms	15 lb = 7 kg
STEP 2 Multiply by 50 mg	7 kg x 50 mg = 350 mg/kg
STEP 3 Round to nearest dose (250 mg increments)	Round up to 500 mg
STEP 4 Divide total into 2 or 3 daily doses	Divide into 2 doses/day: 250 mg + 250 mg
1 YEAR AND OLDER
BODY WEIGHT	15 lb – 22 lb^b
STEP 1 Convert weight to kilograms	18 lb = 8.2 kg
STEP 2 Multiply by 50 mg	8.2 kg x 50 mg = 410 mg/kg
STEP 3 Round to nearest dose (250 mg increments)	Round up to 500 mg
STEP 4 Divide total into 2 or 3 daily doses	Divide into 2 doses/day: 250 mg + 250 mg
1 YEAR AND OLDER
BODY WEIGHT	22 lb +
STEP 1 Convert weight to kilograms	30 lb = 13.6 kg
STEP 2 Multiply by 50 mg	13.6 kg x 50 mg = 680 mg/kg
STEP 3 Round to nearest dose (250 mg increments)	Round up to 750 mg
STEP 4 Divide total into 2 or 3 daily doses	Divide into 2 doses/day: 250 mg + 500 mg – OR – Divide into 3 doses/day: 250 mg + 250 mg + 250 mg

^aDosing frequency should not exceed twice daily to limit free water administration.

^bDosing frequency should not exceed twice daily to avoid overexposures.

OVERALL SEIZURE FREQUENCY	STP + CLB (n=35)	STP + CLB + VPA (n=48)
Marked reduction	17 (35%)	17 (35%)
Mild reduction	13 (27%)	13 (27%)
No Change	16 (33%)	16 (33%)
Mild worsening	2 (4%)	2 (4%)
Marked worsening	0 (0%)	0 (0%)

STP + CLB (n=35)
Marked reduction	17 (35%)
Mild reduction	13 (27%)
No Change	16 (33%)
Mild worsening	2 (4%)
Marked worsening	0 (0%)
STP + CLB + VPA (n=48)
Marked reduction	17 (35%)
Mild reduction	13 (27%)
No Change	16 (33%)
Mild worsening	2 (4%)
Marked worsening	0 (0%)

STP = stiripentol; CLB = clobazam; VPA = valproate

Two strengths

Two dosing forms

G40.83: Dravet syndrome, polymorphic epilepsy in infancy (PMEI) or severe myoclonic epilepsy in infancy (SMEI)

G40.833: Dravet syndrome, intractable, with status epilepticus

G40.834: Dravet syndrome, intractable, without status epilepticus

Fax the following to the specialty pharmacy at 833-871-4137

A completed Patient Enrollment Form.
A copy of your patient’s insurance card (front and back).
A prescription with clear dosing and titration instructions.
List of your patient’s current medications.
Your patient’s medical records.

Tip: Ensure your patient’s chart has a Dravet diagnosis code:

Dravet syndrome (G40.83), polymorphic epilepsy in infancy (PMEI) or severe myoclonic epilepsy in infancy (SMEI)
Dravet syndrome, intractable, with status epilepticus (G40.833)
Dravet syndrome, intractable, without status epilepticus (G40.834)

Complete prior authorization request (if applicable)

Work with the specialty pharmacy to complete and submit required payer forms.
If needed, complete a letter of medical necessity.
If needed, complete a letter of appeal.

Stay connected and follow up

Notify your patient or their caregiver that the specialty pharmacy will reach out to coordinate shipment and delivery.
Save the Biocodex By Your Side number: 833-248-0467.

About DIACOMIT (stiripentol)
DIACOMIT’s has 25 years of clinical experience and extensive data collection and analysis.7,36,37

DIACOMIT Efficacy and Safety Guide

Download this guide for information on studies illustrating DIACOMIT’s efficacy and safety profile.

Download Guide

Drug Interactions Card

Keep this list handy to check the documented and potential drug interactions with DIACOMIT.

Download Card

Efficacy Poster

Review this summary of a study that investigated the perceived efficacy of DIACOMIT.

Download Efficacy Poster

Dosing Poster

Review this summary of a study that explored DIACOMIT dosing practices.

Download Dosing Poster

A Caregiver’s Guide to DIACOMIT

Share this brochure with caregivers of patients with Dravet syndrome to help them learn about DIACOMIT.

Download Caregiver's Guide

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