hero image
Not an actual patient

Information for Healthcare Providers

DIACOMIT® (stiripentol) is an effective, FDA-approved medication that was developed specifically to treat seizures associated with Dravet syndrome. It is indicated for patients 6 months and older (weighing 15 lb or more) taking clobazam. There are no clinical data to support the use of DIACOMIT as a monotherapy.1

Convenient Dosing Options

DIACOMIT is available in 250 mg and 500 mg dosages, with two convenient dosing forms: capsules and fruit-flavored powder. Both forms can be stored at room temperature, making it easy for your patients to take it on the go.

Calculating the Proper Dose

DIACOMIT is indicated for patients 6 months and older who weigh 7 kg (15 lb) or more. The recommended oral dosage of DIACOMIT is 50 mg/kg/day, divided into two or three doses (i.e., 16.67 mg/kg three times daily or 25 mg/kg two times daily), depending on your patient’s age and weight.

In the event of a missed dose, DIACOMIT should be taken as soon as possible. If it is almost time for the next dose, the patient should not take the missed dose. Doses should not be doubled. The total maximum dosage is 3,000 mg/day.

6 MONTHS TO < 1 YEARa,b

1 YEAR AND OLDER

BODY WEIGHT

15 lb +

15 lb-22 lbb

22 lb +

STEP 1

Convert weight to kilograms

15 lb = 7 kg

18 lb = 8.2 kg

30 lb = 13.6 kg

STEP 2

Multiply by 50 mg

7 kg x 50 mg = 350 mg/kg

8.2 kg x 50 mg = 410 mg/kg

13.6 kg x 50 mg = 680 mg/kg

STEP 3

Round to nearest dose (250 mg increments)

Round up to 500 mg

Round up to 500 mg

Round up to 750 mg

STEP 4

Divide total into 2 or 3 daily doses

Divide into 2 doses/day: 250 mg + 250 mg

Divide into 2 doses/day: 250 mg + 250 mg

Divide into 2 doses/day: 250 mg + 500 mg

OR

Divide into 3 doses/day: 250 mg + 250 mg + 250 mg

6 MONTHS TO <1 YEARa,b

BODY WEIGHT

15 lb +

STEP 1

Convert weight to kilograms

/th>

15 lb = 7 kg

STEP 2

Multiply by 50 mg

7 kg x 50 mg = 350 mg/kg

STEP 3

Round to nearest dose (250 mg increments)

Round up to 500 mg

STEP 4

Divide total into 2 or 3 daily doses

Divide into 2 doses/day: 250 mg + 250 mg

1 YEAR AND OLDER

BODY WEIGHT

15 lb – 22 lbb

STEP 1

Convert weight to kilograms

18 lb = 8.2 kg

STEP 2

Multiply by 50 mg

8.2 kg x 50 mg = 410 mg/kg

STEP 3

Round to nearest dose (250 mg increments)

Round up to 500 mg

STEP 4

Divide total into 2 or 3 daily doses

Divide into 2 doses/day: 250 mg + 250 mg

1 YEAR AND OLDER

BODY WEIGHT

22 lb +

STEP 1

onvert weight to kilograms

30 lb = 13.6 kg

STEP 2

Multiply by 50 mg

13.6 kg x 50 mg = 680 mg/kg

STEP 3

Round to nearest dose (250 mg increments)

Round up to 750 mg

STEP 4

Divide total into 2 or 3 daily doses

Divide into 2 doses/day: 250 mg + 500 mg

OR

Divide into 3 doses/day: 250 mg + 250 mg + 250 mg

aDosing frequency should not exceed twice daily to limit free water administration.
bDosing frequency should not exceed twice daily to avoid overexposures.

For further instruction, please download the full Prescribing Information.

img banner Julia, age 7, actual patient on DIACOMIT

Documenting a Diagnosis

In late 2020, new ICD-10 codes were approved for Dravet syndrome. As you update your patient’s treatment plan to include DIACOMIT, check their record for the following codes:

G40.83: Dravet syndrome, polymorphic epilepsy in infancy (PMEI) or severe myoclonic epilepsy in infancy (SMEI)


G40.833: Dravet syndrome, intractable, with status epilepticus


G40.834: Dravet syndrome, intractable, without status epilepticus

 

Logging the proper codes can help prevent delays in the access process.

Read the DIACOMIT Access Guide

Our quick checklist outlines what you need to share with our specialty pharmacy to get your patients the treatment they need.

Download Guide

DIACOMIT (stiripentol) Pharmacology

Although the exact mechanism by which DIACOMIT exerts its anticonvulsant effect in humans is unknown, there are two possible mechanisms of action:1

Direct Mediation of GABAA Receptors

Stiripentol is thought to increase activity of GABAA receptors, which enhances GABAergic neurotransmission to block an action potential.1

One study found that stiripentol had the most positive effect on GABAA receptors with an alpha-3 subunit. Since that subunit occurs at the highest levels during youth, it may explain stiripentol’s efficacy in treating a pediatric epilepsy.38

Indirect Effects on Cytochrome P450 Activity

Stiripentol may inhibit cytochrome P450 enzymes, which break down several commonly used antiepileptic drugs, like clobazam. This may enable those drugs to last longer.1,38

In clinical studies, stiripentol increased concentrations of clobazam by about twofold and norclobazam (its active metabolite) by fivefold.1